Role of nitric oxide in the pathogenesis of dengue.

Abstract

The free radical nitric oxide (‎NO)‎ has emerged in recent years as a fundamental signalling molecule for the maintenance of homeostasis, as well as a potent cytotoxic effector involved in the pathogenesis of a wide range of human diseases. The presence of NO during dengue infection as well as its experimental antiviral and apoptotic effects have been documented. In this regard, increased serum NO levels in dengue fever and basal levels in the haemorrhagic form of dengue have been reported. Clinical and experimental data suggest that NO could act as a beneficial factor during dengue infection by its antiviral and apoptotic effects; however, more intense investigations are required.