In vivo antiplatelet effect of intravenous alum in rabbits
Other Titles
Abstract
Traditionally known as a haemostatic agent, alum shows a paradoxical effect of increased prothrombin and partial thromboplastin times. This study investigated the in vivo effect of alum on platelet aggregation and bleeding time in rabbits. The collagen-induced platelet aggregation of platelet-rich plasma samples from 14 healthy rabbits was measured turbidometrically using a platelet aggregometer, before and 1 hour after intravenous injection of alum. Collagen-induced platelet aggregation was significantly reduced after alum injection. Bleeding time from an ear puncture in 8 rabbits was also significantly prolonged after intravenous alum injection. These results suggest that the use of alum as an oral antiplatelet drug could be explored further, taking into account possible side-effects especially in renal compromised patients
Citation
Mohammed, F.I. & Shafagoj, Y.A. (2005). In vivo antiplatelet effect of intravenous alum in rabbits. EMHJ - Eastern Mediterranean Health Journal, 11 (3), 442-448, 2005, https://iris.who.int/handle/10665/116965
Journal
EMHJ - Eastern Mediterranean Health Journal, 11 (3), 442-448, 2005
Relation
Temporal Coverage
Statement of Responsibility
Description
442-448
Table of Contents
Version
Sponsorship
PMID
PMCID
Document number
ISBN
ISSN
1020-3397
ISMN
Identifiers
Other Identifiers
http://applications.emro.who.int/emhj/1103/11_3_2005_442_448.pdf
Format
Language
English