Bashawri, L.A.M.2014-06-172014-06-172007-12-311020-3397http://applications.emro.who.int/emhj/1305/13_5_2007_1181_1189.pdfhttps://iris.who.int/handle/10665/1173641181-1189This study in King Fahd Hospital of the University, Saudi Arabia, assessed the frequency of alloimmunization to red cell antigens in sickle-cell anaemia patients over 1996-2004 in order to evaluate the risk of alloimmunization and identify the most common alloantibodies. A retrospective analysis of the transfusion history and medical records of 350 patients aged 2 to 75 years who had received at least 1 transfusion found that 48 patients had developed alloantibodies [13.7%]. The most common alloantibodies detected were: anti-E alone [18.8%], nonspecific [12.5%], inconclusive [12.5%], anti-K [10.4%] and anti-c 3 [6.3%]. Some patients had 1 alloantibody, while others more than 1 and even multiple antibodies. Nine patients had a persistent positive direct antiglobulin testenErythrocytesBlood TransfusionIsoantibodiesAnemia, Sickle Cell